Information for researchers

What are biomarkers?

Biological markers which can be detected in the human body through a range of tests can enable doctors to do various things for a disease. They can be divided as:
  • Diagnostic biomarkers: enable early diagnosis
  • Prognostic biomarkers: define patients' requirements for additional treatment
  • Predictive biomarkers: Define the type of treatment
    • Pharmacodynamics: how patient may respond to treatment for e.g., how a drug/medicine may be distributed in body and what effect/side-effect it may have
    • Efficacy response: whether patients are responding to treatment

How is PCRFTB enabling biomarker research?

  • To develop a diagnostic test, PCRFTB can allow researchers to access samples that are
    • uniformly collected
    • reliably stored
    • clinically annotated
  • PCRFTB consents patients who are often seen by diverse specialities in clinics at different sites
  • PCRFTB encourages collaboration between clinicians working in different specialities and scientists with distinct expertise.

What are the emerging opportunities in research and treatment of cancer patients?

  • More effective treatments
  • Centralisation of services leads to highly experienced teams with efficient protocols
  • Cutting edge technologies in research such as
    • Next generation sequencing
    • Proteomics, metabolomics, and other -omics platforms
    • Cell and molecular biology
    • Targeted treatment regimens
    • Bioinformatics and IT